課程名稱 |
生醫物理 Physics for Medicine and Biology |
開課學期 |
108-2 |
授課對象 |
工學院 醫學工程學研究所 |
授課教師 |
林文澧 |
課號 |
DBME7052 |
課程識別碼 |
528 M0870 |
班次 |
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學分 |
3.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期五7,8,9(14:20~17:20) |
上課地點 |
基醫503 |
備註 |
本課程中文授課,使用英文教科書。教室:基醫大樓503室。 總人數上限:30人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1082DBME7052_ |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
1. Exponential growth and decay: decay with multiple half-lives, logistic equation, etc.
2. System of many particles: Microstates and macrostates, energy of a system, thermal equilibrium, entropy, Boltzmann factor, Nernst equation, chemical potential, Gibbs free energy, etc.
3. Transport in an infinite medium:Flux, continuity, solvent drag, diffusion, steady-state diffusion to a spherical cell and effects, drift and diffusion in 1-D, etc.
4. Transport through neutral membranes:Membrane, osmotic press, solute transport, artificial kidney, countercurrent transport, volume and solute transport in a pore, etc.
5. Impulses in nerve and muscle cell:Properties of nerves, electric field, charge distribution, leakage current, nerve impulse, electrotonus, Hodgkin-Huxley model for membrane current, propagation of nerve impulse, rhythmic eletrical activity, etc.
6. Exterior potential and Electrocardiogram (ECG): Potential outside an axon, exterior potential for a pulse, ECG, electrical stimulation, electroencephalogram (EEG), etc.
7. Biomagnetism: Magnetic field around an axon, magnetocardiogram (MCG),magnetoencephalogram (MEG), magnetic stimulation, etc.
8. Electricity and magnetism at the cellular level: Donnan equilibrium, ion movement in solution, membrane channels, sensory transducer, possible effects of weak external electrical and magnetic fields, etc.
9. Biofeedback and control: Feedback loop with time constants, difference equations and chaotic behavior, feedback loop wth a fixed dalay, etc.
持續改善:因應每屆修課學生背景不同而調整授課內容或難易度 |
課程目標 |
以微觀的觀點探討生物的一些物理特性 |
課程要求 |
期未報告:
一人交一份期未報告
於期末前兩週公佈相關題目
依題目要求尋找三至五篇相關paper
整理成一份書面報告及簡報檔
並於學期未上台做十五~二十分鐘的內容報告。 |
預期每週課後學習時數 |
|
Office Hours |
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指定閱讀 |
無 |
參考書目 |
1.Intermediate Physics for Medicine and Biology, 3rd Edition, Hobbie RK, AIP Press, 1997.
2.The physical basis of Biochemistry: The Foundations of Molecular Biophysics, Bergethon PR, Springer-Verlag, 1998. |
評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
期末報告 |
50% |
|
2. |
期末報告 |
50% |
|
|
週次 |
日期 |
單元主題 |
第1週 |
2/21 |
Exponential growth and decay: decay with multiple half-lives, logistic equation
融合基礎知識,發掘並有效解決重要問題 |
第2週 |
2/28 |
System of many particles: Microstates and macrostates, energy of a system, thermal equilibrium, entropy, Boltzmann factor, Nernst equation, chemical potential, Gibbs free energy
融合基礎知識,發掘並有效解決重要問題 |
第3週 |
3/06 |
System of many particles: Microstates and macrostates, energy of a system, thermal equilibrium, entropy, Boltzmann factor, Nernst equation, chemical potential, Gibbs free energy
融合基礎知識,發掘並有效解決重要問題 |
第4週 |
3/13 |
System of many particles: Microstates and macrostates, energy of a system, thermal equilibrium, entropy, Boltzmann factor, Nernst equation, chemical potential, Gibbs free energy
融合基礎知識,發掘並有效解決重要問題 |
第5週 |
3/20 |
Transport in an infinite medium:Flux, continuity, solvent drag, diffusion, steady-state diffusion to a spherical cell and effects, drift and diffusion in 1-D
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第6週 |
3/27 |
Transport in an infinite medium:Flux, continuity, solvent drag, diffusion, steady-state diffusion to a spherical cell and effects, drift and diffusion in 1-D
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第7週 |
4/03 |
Transport through neutral membranes:Membrane, osmotic press, solute transport, artificial kidney, countercurrent transport, volume and solute transport in a pore
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第8週 |
4/10 |
Transport through neutral membranes:Membrane, osmotic press, solute transport, artificial kidney, countercurrent transport, volume and solute transport in a pore
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第9週 |
4/17 |
Impulses in nerve and muscle cell:Properties of nerves, electric field, charge distribution, leakage current, nerve impulse, electrotonus, Hodgkin-Huxley model for membrane current, propagation of nerve impulse, rhythmic eletrical activity
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第10週 |
4/24 |
Impulses in nerve and muscle cell:Properties of nerves, electric field, charge distribution, leakage current, nerve impulse, electrotonus, Hodgkin-Huxley model for membrane current, propagation of nerve impulse, rhythmic eletrical activity
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第11週 |
5/01 |
Exterior potential and Electrocardiogram (ECG): Potential outside an axon, exterior potential for a pulse, ECG, electrical stimulation, electroencephalogram (EEG)
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第12週 |
5/08 |
Exterior potential and Electrocardiogram (ECG): Potential outside an axon, exterior potential for a pulse, ECG, electrical stimulation, electroencephalogram (EEG)
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第13週 |
5/15 |
Biomagnetism: Magnetic field around an axon, magnetocardiogram (MCG),magnetoencephalogram (MEG), magnetic stimulation
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第14週 |
5/22 |
Electricity and magnetism at the cellular level: Donnan equilibrium, ion movement in solution, membrane channels, sensory transducer, possible effects of weak external electrical and magnetic fields
厚植學識傳承、工程科技、臨床醫學、生命科學與知識管理的跨領域專業技能 |
第15週 |
5/29 |
Biofeedback and control: Feedback loop with time constants, difference equations and chaotic behavior, feedback loop wth a fixed dalay
培養多元整合與團隊合作的精神 |
第16週 |
6/05 |
期末考 |
第17週 |
6/12 |
期末口頭報告
培養終身自我學習成長的能力 |
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